Cell culture scaffolds based on concentric shape constructs, such as circles, provide a consistent variability of pore size (heterogenous pore size and distribution) emanating from the centre to the periphery of said scaffold. The effect is to provide clear regions of the scaffold where cells will have more favourable nutrient and oxygen exchange (periphery) and areas not so (centre). Such a construct better represents physiological conditions in the body providing tangible experimental advantages for research in fields studying cell microenvironments.