INTRODUCING COPNER BIOTECH PIONEERS IN
3D PETG SCAFFOLDS


3D EXTRUSION
BIO PRINTERS

3D NEGATIVE SPACE
INKJET BIO PRINTERS

GRAPE UK® PROPRIETARY
3D MODELLING DATA
FORMAT

Establishing a culture of innovation in Biotechnology.

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ABOUT

Established in 2020, Copner Biotech is a biotechnology company based in Ebbw Vale, Wales, with its focus in 3D cell culture and associated technologies. What started as an initial concept of next generation 3D printing technology, has gone from strength to strength, creating an impressive portfolio of technologies, products and services to the 3D cell culture markets.

Traditionally, mammalian cells are grown in a 2-dimensional environment, such as petri dishes, but this is not without its setbacks, namely the forced polarity that cells undergo due to the nature of the culture environment.

Cells grown 3-dimensionally exhibit more physiologically relevant characteristics.

Copner Biotech's state of the art design and manufacturing process enables 3D cell culture scaffolds to be produced based on concentric shape constructs, such as circles, providing a consistent variability of pore size (heterogenous pore size and distribution) emanating from the centre to the periphery of scaffold.

The effect is to provide clear regions of the scaffold where cells will have more favourable nutrient and oxygen exchange (periphery)and areas not so (centre). Such constructs better represents physiological conditions in the body providing tangible experimental advantages for research in fields studying cell microenvironments.

Our novel and proprietary GRAPE UK® 3D modelling format enables users to model and print highly precise 3D constructs, with high batch-to-batch consistency.

With our next generation 3D modelling software, users can design and create complex, microarchitectures directly applicable to 3D cell culture and tissue engineering applications; for example the cultivation and subsequent convenient extraction of spheroids.

Spheroids are a type of three-dimensional cell modeling that better simulate a live cell's environmental; specifically regarding the reactions between cells and between cells and the matrix.

The efficacy of an original scaffold design has been the subject of a collaboration project with Swansea University realising fantastic cell culture results. These scaffolds are now available through life sciences vendor 2BScientific.

Bioprinting is the 3D printing of biological materials, which may or may not be laden with mammalian cells. The predominant use of bioprinting is the production of tissue like structures for drug testing, with more and more large companies looking towards this technology as an alternative to animal testing.

Copner Biotech’s novel approach to bioprinting couples microfluidic droplet deposition with raster-style, sequential printer head movement.

This method of deposition is firstly optimised to the user’s own Bioink via our, ‘droplet optimisation protocol’ before users can print personalised 3D constructs.

Microfluidic droplet deposition performed in this manner unlocks a new level of precision and control during the bioprinting process.

Early Adopter's Program : Copner Biotech is currently accepting prototype pre-orders for it's disruptive 3D bio extrusion printer system GRAPE S1. GRAPE S1 includes high precision 3D extrusion bio printer powered by GRAPE UK® control software; bundled with GRAPE UK® 3D modelling software

In the long term, Copner Biotech will ultimately aim to establish a foothold in the bioprinting market. We will do this via innovative, industrial collaborations with like-minded companies already in this space, utilising our novel technology. We continue to work upon and develop our existing technologies, in the software and 3D printing hardware space, to create competitive products.

Currently in collaboration with Jellagen part funded with a SMART Cymru Innovation Award of £123,724.
Jellagen world leaders in Marine Biotechnologies developing an innovative BioINK based on Jellyfish Collagen Type 0 to be printed with the Next Generation 3D Bio Printer GRAPE S1 developed by Copner Biotech

Copner Biotech are working with researchers at Cardiff University School of Biosciences to validate our 3D PETG scaffolds when applied to novel forms of microscopy research.
This collaboration will further establish our 3D PETG scaffold capabilities to be at the forefront of 3D cell culture technology.

Accelerate Healthcare Technology Centre Research Collaboration.

Copner Biotech's CEO and Accelerate Healthcare Technology Centre scientists complete their collaborative research on the efficacy of our 3D PETG cell culture scaffold technology.

Accelerate Healthcare Technology Centre .... "this novel 3D cell culture platform offers enormous potential for research into multiple cell types, including: cancer cells, cardiomyocytes, fibroblasts and liver cells. Experts believe that the applications for this product are genuinely limitless, and the reality is that researchers are routinely discovering new opportunities provided by these advanced scaffold designs"

3D PETG Cell Culture Scaffold

3D PETG Scaffold - GHP International Cell Culture Award 2021.

SCAFFOLD PROSPECTUS
Plate of 3D PETG Cell Culture Scaffolds

Deployment of 3D PETG Scaffolds.

SEM Images of 3D PETG Cell Culture Scaffold

SEM Images of Fibroblast L929 cells grown on 3D PETG Scaffold.

Spheroids harvested from uncoated 3D PETG Scaffold

Dermal Spheroids established on uncoated 3D PETG Scaffold.

Spheroid harvested from uncoated 3D PETG Scaffold

Dermal Spheroid harvested from uncoated 3D PETG Scaffold.

Smart Cymru Logo

Smart Cymru Innovation Award.

Biotech information

Design and manufacture of 3D cell culture scaffolds based on concentric shape constructs

Design and manufacture of 3D Extrusion and Negative Space Inkjet Bio Printers

Inventors of Graphical Rectangular Actual Positional Encoding (GRAPE UK®) 3D Modelling Data Format

3D Modelling

High Precision Data Modelling

3D PETG Scaffold

Cell Culture Research

GRAPE UK®

Graphical Rectangular Actual Positional Encoding

High Precision 3D Inkjet Bio Printer

Innovate UK Part Funded Project

3D Extrusion Bio Printer - GRAPE S1

SMART Cymru Part Funded Development

Collaborator Beta Testing

3D PETG Scaffolds available for Beta Testing with new collaborators.

Bespoke 3D PETG Scaffolds.

PETG Scaffolds can be fabricated to your exact requirements.

LET's TALK

For your exacting requirements in Cell Culture 3D PETG Scaffolds.

The latest innovation in the field of 3D Bio Printing .

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