Design and manufacture of cell culture scaffolds based on concentric shape constructs,
such as circles, providing a consistent variability of pore size (heterogenous pore
size and distribution) emanating from the centre to the periphery of said scaffold.
The effect is to provide clear regions of the scaffold where cells will have more
favourable nutrient and oxygen exchange (periphery) and areas not so (centre).
Such a construct better represents physiological conditions in the body providing
tangible experimental advantages for research in fields studying cell microenvironments.
The total surface area and pore sizes exhibited by the scaffolds depend on the overall
structure of the scaffold. This includes the number and size of the supports/struts
within the support layers, the pattern in which the supports/struts are placed,the
geometry of the concentric shapes layers, and the order and combinations of layers employed.
Shape constructs within concentric shape layers can be spaced apart in a controlled fashion,
as selected by the designer, in order to define the open channel dimensions between shape constructs.
The space/gap between concentric shape layers as realised by the support layers can range from
small (50-100 microns) to large (100-400 microns) or a mixture of the two.
The pore sizes within the complete scaffold vary, ranging anywhere from 10 to 1000 microns.
The pores of the scaffold are all interconnected, promising an internal space for cells to
infiltrate and adhere, either to one another, or the internal/external surface of the scaffold.
Using our bespoke Bio Scaffold modelling software our designers can produce scaffolds
to your required specification.
Alternatively our library 3D PETG Scaffolds having consistent structure, with heterogenous
porosity are available to purchase through our UK distributor 2BScientific.
Copner Biotech's CEO and Accelerate Healthcare Technology Centre scientists complete their
collaborative research on the efficacy of our 3D PETG cell culture scaffold technology.
Accelerate Healthcare Technology Centre ...."this novel 3D cell culture platform offers enormous potential for
research into multiple cell types, including: cancer cells, cardiomyocytes,
fibroblasts and liver cells. Experts believe that the applications for this
product are genuinely limitless, and the reality is that researchers are routinely
discovering new opportunities provided by these advanced scaffold designs"